HDAC

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52W High price	$0.15
52W High date	20th Sep 2021 (3 years ago)
All Time High (ATH) Date	31st Dec 2025 (1 month ago)
All Time Low (ATL) Date	31st Dec 2025 (1 month ago)

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Histone Deacetylases (HDACs) are evolutionary conserved enzymes that remove acetyl groups from histones and other proteins. They operate by using zinc ions as cofactors, which are coordinated by specific amino acid residues and involved in the stabilization of acetyl-lysine in the catalytic pocket. HDACs regulate the homeostasis of histone acetylat...

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Histone Deacetylases (HDACs) are evolutionary conserved enzymes that remove acetyl groups from histones and other proteins. They operate by using zinc ions as cofactors, which are coordinated by specific amino acid residues and involved in the stabilization of acetyl-lysine in the catalytic pocket. HDACs regulate the homeostasis of histone acetylation and are known to interact with non-histone proteins, playing a crucial role in gene regulation. There are four major classes of HDACs, distinguished by their homology to yeast: Class I, Class IIa, Class IIb, and Class IV, each with distinct localizations and activities within the cell. These enzymes have garnered significant attention as therapeutic targets for various diseases including cancer and Alzheimer's disease.

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